We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
378 Hydroxypropyl beta cyclodextrin barrier prevents respiratory and eye viral infections.
- Authors
Asante, Isaac; Lu, Angela; Humayun, Mark; Louie, Stan
- Abstract
The given document is an abstract from the Journal of Clinical & Translational Science. The first part of the abstract discusses a study on motor dysfunction in patients with multiple sclerosis (MS). The study used high-density surface EMG to analyze motor unit variables in 11 ambulatory patients with MS. The results showed consistent differences in motor unit variables between MS patients and controls, suggesting disruptions in excitatory, inhibitory, and neuromodulatory components of the voluntary motor command in MS. The second part of the abstract discusses a novel barrier made of hydroxypropyl beta cyclodextrin that has been shown to be effective in preventing respiratory coronavirus infections in mice models. The barrier reduced viral load and inflammatory responses in the lungs of treated mice. The authors suggest that this barrier could reduce the transmission and burden of respiratory and eye viral infections in humans. The third part of the abstract mentions a study on fetal natural killer (NK) cells exposed to human cytomegalovirus (HCMV) infection during gestation. The objective of the study was to define the transcriptomes of these cells. Umbilical cord blood and tissue samples were collected from HCMV+ and HCMV- fetuses, and single-cell RNA sequencing was performed. The results of the study are not provided in the abstract.
- Publication
Journal of Clinical & Translational Science, 2024, Vol 8, p113
- ISSN
2059-8661
- Publication type
Abstract
- DOI
10.1017/cts.2024.332