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- Title
Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex.
- Authors
Di Lazzaro, V.; Oliviero, A.; Berardelli, A.; Mazzone, P.; Insola, A.; Pilato, F.; Saturno, E.; Dileone, M.; Tonali, P. A.; Rothwell, J. C.
- Abstract
The effects of repetitive transcranial magnetic stimulation (rTMS; 20 stimuli at 5 Hz at 120% resting motor threshold intensity using a biphasic stimulus pulse) on the excitability of human motor cortex were investigated in two patients who had an electrode implanted into the cervical epidural space. The corticospinal D wave increased in amplitude with successive stimuli, and reached a maximum after three or five pulses. At this stage, the amplitude of the I waves was unchanged, but after a further 10 stimuli an additional I wave was recruited. Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS.
- Subjects
FRONTAL lobe; CEREBRAL cortex; MOTOR cortex; PREFRONTAL cortex; MAGNETICS; RESEARCH
- Publication
Experimental Brain Research, 2002, Vol 144, Issue 4, p549
- ISSN
0014-4819
- Publication type
Article
- DOI
10.1007/s00221-002-1106-9