We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigation of Mechanisms Involved in (−)-Borneol-Induced Vasorelaxant Response on Rat Thoracic Aorta.
- Authors
Silva-Filho, José Couras; Oliveira, Nelma Neylanne P. M.; Arcanjo, Daniel D. R.; Quintans-Júnior, Lucindo J.; Cavalcanti, Sócrates C. H.; Santos, Márcio Roberto V.; Oliveira, Rita de Cássia M.; Oliveira, Aldeídia P.
- Abstract
The monoterpene (−)-borneol is present in essential oils of several medicinal plants. The aim of this study was to evaluate (−)-borneol effects on rat thoracic aorta artery rings. The cumulative addition of (−)-borneol (10−9-3 × 10−4 M) on a phenylephrine-induced pre-contraction (10−6 M) promoted a vasorelaxant effect in a concentration-dependent manner and independent of vascular endothelium. A similar effect was obtained on KCl-induced pre-contractions (80 mM). (−)-Borneol (10−5-3 × 10−4 M) inhibited contractions induced by cumulative addition of CaCl2 (10−6-3 × 10−2 M) in depolarizing medium without Ca2+ in a concentration-dependent manner. On S-(−) Bay K 8644-induced pre-contractions (10−7 M), (−)-borneol did not induce significant changes compared with KCl-induced pre-contractions. In a Ca2+-free medium, (−)-borneol (10−5, 10−4 or 10−3 M) interfered in calcium mobilization from phenylephrine (10−6 M)- or caffeine (20 mM)-sensitive intracellular stores. The involvement of K+ channels was evaluated by tetraethylammonium (3 mM), 4-aminopyridine (1 mM) and glibenclamide (10−5 M) pre-treatment, and (−)-borneol-induced vasorelaxation was markedly attenuated. Thus, this vasorelaxant effect can probably be attributed to calcium influx blockade through voltage-operated calcium channels (CaVL), calcium mobilization from intracellular stores and potassium channels activation.
- Subjects
MONOTERPENES; TERPENES; LABORATORY rats; CLINICAL trials; MEDICAL research
- Publication
Basic & Clinical Pharmacology & Toxicology, 2012, Vol 110, Issue 2, p171
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2011.00784.x