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- Title
Multimodality pictorial review of IgG4-related disease in the abdomen and pelvis.
- Authors
Czerniak, Suzanne; Rao, Aditya; Mathur, Mahan
- Abstract
Background: Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated disease that can affect multiple organs, including the orbits, salivary glands, thyroid gland, lungs, aorta, pancreas, bile ducts, lymph nodes, and retroperitoneum. While timely diagnosis is particularly important given the efficacy of glucocorticoid treatment for IgG4-RD, accurate recognition can prove a challenge given the overlap between the imaging features of this disease and other entities. Purpose: After a review of the epidemiology, pathophysiology, and clinical considerations (including treatment) associated with IgG4-RD, this pictorial review will showcase the variable imaging manifestations of this disease in the abdomen and pelvis. Post-treatment imaging appearance of these entities will be reviewed and mimickers of this disease in the abdomen and pelvis will be presented. Conclusion: The presence of mass-like soft tissue with radiographic characteristics of fibrosis affecting multiple organs should raise suspicion for IgG4-RD, although definite diagnosis can only be made with appropriate clinical, serological, and pathologic data.
- Subjects
ABDOMINAL diseases; PELVIS; BILE ducts; THYROID gland; ORBITS (Astronomy); ABDOMEN; SALIVARY glands
- Publication
Abdominal Radiology, 2023, Vol 48, Issue 10, p3147
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-023-03996-w