We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers.
- Authors
Semmler, Amelie; Mundorf, Anna Katharina; Kuechler, Anna Sabrina; Schulze-Bosse, Karin; Heidecke, Harald; Schulze-Forster, Kai; Schott, Matthias; Uhrberg, Markus; Weinhold, Sandra; Lackner, Karl J.; Pawlitzki, Marc; Meuth, Sven Guenther; Boege, Fritz; Ruhrländer, Jana
- Abstract
SARS-CoV-2 mRNA vaccination can entail chronic fatigue/dysautonomia tentatively termed post-acute COVID-19 vaccination syndrome (PACVS). We explored receptor autoantibodies and interleukin-6 (IL-6) as somatic correlates of PACVS. Blood markers determined before and six months after first-time SARS-CoV-2 vaccination of healthy controls (N = 89; 71 females; mean/median age: 39/49 years) were compared with corresponding values of PACVS-affected persons (N = 191; 159 females; mean/median age: 40/39 years) exhibiting chronic fatigue/dysautonomia (≥three symptoms for ≥five months after the last SARS-CoV-2 mRNA vaccination) not due to SARS-CoV-2 infection and/or confounding diseases/medications. Normal vaccination response encompassed decreases in 11 receptor antibodies (by 25–50%, p < 0.0001), increases in two receptor antibodies (by 15–25%, p < 0.0001) and normal IL-6. In PACVS, serological vaccination–response appeared significantly (p < 0.0001) altered, allowing discrimination from normal post-vaccination state (sensitivity = 90%, p < 0.0001) by increased Angiotensin II type 1 receptor antibodies (cut-off ≤ 10.7 U/mL, ROC-AUC = 0.824 ± 0.027), decreased alpha-2B adrenergic receptor antibodies (cut-off ≥ 25.2 U/mL, ROC-AUC = 0.828 ± 0.025) and increased IL-6 (cut-off ≤ 2.3 pg/mL, ROC-AUC = 0.850 ± 0.022). PACVS is thus indicated as a somatic syndrome delineated/detectable by diagnostic blood markers.
- Subjects
DYSAUTONOMIA; FATIGUE (Physiology); COVID-19 vaccines; RECEPTOR antibodies; VACCINATION; ADRENERGIC receptors
- Publication
Vaccines, 2023, Vol 11, Issue 11, p1642
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11111642