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- Title
Antibody Response against Circulating Omicron Variants 8 Months after the Third Dose of mRNA Vaccine.
- Authors
Anichini, Gabriele; Terrosi, Chiara; Gori Savellini, Gianni; Gandolfo, Claudia; Barbagli, Francesca; Carta, Giulio Alberto; Fabrizi, Simonetta; Miceli, Giovanni Battista; Cusi, Maria Grazia
- Abstract
The COVID-19 wave is being recently propelled by BA.2 and, particularly, BA.5 lineages, showing clear transmission advantages over the previously circulating strains. In this study, neutralizing antibody responses against SARS-CoV-2 Wild-Type, BA.2 and BA.5 Omicron sublineages were evaluated among vaccinees, uninfected or infected with Omicron BA.1 strain, 8 months after the third dose of SARS-CoV-2 vaccine. The aim of this study was to compare the cross-protective humoral response to the currently circulating variant strains induced by vaccination, followed by Omicron infection in some subjects. Results showed a low antibody titer against all three variants in uninfected vaccinated subjects. On the other hand, vaccinated subjects, infected with BA.1 variant after receiving the third dose (about 40 days later), showed a strong response against both BA.2 and BA.5 strains, albeit with lower titers. This reinforces the concept that vaccination is fundamental to induce an adequate and protective immune response against SARS-CoV-2, but needs to be updated, in order to also widen the range of action towards emerging variants, phylogenetically distant from the Wuhan strain, against which the current formulation is targeted.
- Subjects
WUHAN (China); SARS-CoV-2 Omicron variant; ANTIBODY formation; COVID-19 vaccines; MESSENGER RNA; ANTIBODY titer
- Publication
Vaccines, 2022, Vol 10, Issue 9, p1512
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10091512