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- Title
Spatial distribution of macular pigment estimated by autofluorescence imaging in elderly Japanese individuals.
- Authors
Obana, Akira; Gohto, Yuko; Sasano, Hiroyuki; Gellermann, Werner; Sharifzadeh, Mohsen; Seto, Takahiko; Bernstein, Paul S.
- Abstract
Purpose: To determine the spatial distribution types of macular pigment (MP) in elderly Japanese individuals and to consider their origin. Study design: Observational case series. Methods: Local MP optical density (MPOD) at some eccentricities and MP volume were measured using the MPOD module of a MultiColor Spectralis in 96 pseudophakic eyes of 96 participants (age range, 52–86 years; mean age, 72.8 ± 8.3 years). The MP distribution types were determined from the MP spatial profiles. The retinal thickness (RT) at the foveal center, at both 0.5° and 0.9° eccentricities, and the foveal width were measured using optical coherence tomography. Results: The mean local MPOD at the foveal center was 0.79. Spatial distribution was classified into four types: central peak (24.0%), ring-like (40.6%), intermediate (22.9%), and central dip (12.5%). The ring-like type was the most frequent in these Japanese participants. The central-peak type showed lower MPOD than did the other types in the area outside 0.9°. The ring-like type occurred frequently in eyes with small RT at 0.5° and wider foveal width. A rough contour of the Müller cell cone was found more frequently in the central-dip type than in the other types. Conclusions: The present characteristics of the different distribution patterns could be explained by the hypothesis that MP presents mainly in the Müller cell cone within 0.5° and in Müller cells in the outer and inner plexiform layers in the area outside 0.5°. The anatomic characteristics of Müller cells at the fovea and parafovea likely affect the MP distribution.
- Subjects
BIOFLUORESCENCE; OPTICAL coherence tomography; VISUAL fields; OPACITY (Optics)
- Publication
Japanese Journal of Ophthalmology, 2020, Vol 64, Issue 2, p160
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-020-00716-5