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- Title
The Safety of Lactobacillus Plantarum Extract Used as a Possible Adjuvant Treatment of Breast Cancer.
- Authors
Boonlert, Baramee; Fongcome, Achara; Virarach, Napaporn
- Abstract
Objective: Lactobacillus plantarum is one of the most interesting strains of probiotics with potential anticancer effects. However, few clinical studies have been done to demonstrate this. The objective of the present study was to evaluate clinical safety of Lactobacillus plantarum extract used as an adjuvant treatment for breast cancer. Materials and Methods: This study was a prospective, randomized, double-blind, and placebo-controlled study of early-stage breast cancer patients who underwent surgical removal of tumor and given conventional chemotherapy. The treatment group received products containing L. plantarum extract, and the placebo group received only a placebo for the duration of six months. Evaluated clinical parameters include body weight, symptoms resulting from side effects from chemotherapy, quality of life and laboratory tests. Results: There were 56 patients in the study, of whom 27 were randomly assigned to a treatment group and 29 to the placebo group. A significant difference in the WBC count between the two groups was found in the second month after chemotherapy (P = 0.04). The mean white blood cell (WBC) count in the treatment group was 7,641 cells/mm3 and 5,108 cells/mm3 in placebo group, respectively. The mean bodyweight in the placebo group decreased in the second month to an extent more than in the treatment group, and continue to decrease in the sixth month while in the treatment group the mean bodyweight increased. Conclusions: The present study demonstrated that L. plantarum extract can be used safely as a possible adjuvant therapy for breast cancer patients. There was a trend towards better clinical and laboratory profiles in the treatment group, but mostly without statistical significance. Only the WBC count at the second month of chemotherapy showed a significant difference.
- Subjects
ADJUVANT treatment of cancer; LACTOBACILLUS plantarum; LEUCOCYTES; ANTINEOPLASTIC agents
- Publication
Thai Journal of Surgery, 2022, Vol 43, Issue 3, p105
- ISSN
0125-6068
- Publication type
Article