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- Title
Effect on different intensity of sinusoidal electromagnetic fields on the biomechanical properties in rats.
- Authors
GAO Yuhai; CHEN Kerning; GE Baofeng; ZHOU Jian; MA Xiaoni; LI Shaofeng
- Abstract
Objective To investigate the effect of the different intensity of 50 Hz sinusoidal electromagnetic fields (SEMFs) on the biomcchanical properties in rats. Methods Twenty-four 6-week-old female SD rats were fed for 1 week. They were randomly divided into 3 groups; normal control group. 0.1 mT SEMFs group, and 0.6 mT SEMFs group. Except to rats in the control group, rats in other groups were given SEMFs for 3h every day. After 8 weeks, bone mineral density (BMD) of the whole body was measured using dual-energy X-ray absorptiometry. Bilateral femurs and the tibia were collected. The biomcchanical properties of the left femurs and the vertebrae were tested using; an AG-X multifunctional detector. The microstructure of the rieht femurs was scanned and analyzed using μ-CT. The heart, the liver, the spleen, the lung, the stomach, the kidney, the adrenal gland, and the litems were all collected and weighed. The organ index was calculated and the routine pathological detection was performed. Results The organ index of all the organs showed no significant difference, and the pathological observation also showed no abnormal changes. Comparing to those in control group, the whole body BMD, femur maximum load, clastic modulus, yield strength, the fourth lumbar maximum load, clastic modulus, and bone volume, trabecular number and thickness from micro-CT scans increased significantly in 50 Hz 0.1 mT SEMFs group (P < 0.01). Trabecular separation in 50 Hz 0.1 mT SEMFs group was significantly lower than that in control group (P < 0.01). No statistical difference was found between 50Hz 0.6mT SEMFs group and control group. Conclusion 50 Hz 0.1 mT SEMFs can effectively increase BMD, improve the bone micro-structurc organization and the biomcchanical properties, and reduce the risk of osteoporotic fractures.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 10, p1170
- ISSN
1006-7108
- Publication type
Article