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- Title
Association of Genetic Variants in XPC and XPG Genes with Cervical Cancer Risk in a Rural Population: A Hospital Based Case Control Study.
- Authors
Patil, Madhavi N.; Datkhile, Kailas D.; Durgawale, Pratik P.; Kshirsagar, Nitin S.; Kanetkar, Sujata R.; Kakade, Satish V.
- Abstract
Background: Cervical cancer is a major concern of health risk in urban and rural parts of India.. Aim and Objectives: This study was aimed to find out frequency of polymorphisms in DNA repair genes including Xeroderma pigmentosum complementation group C (XPC) and Xenoderma pigmentosum complementation group G (XPG) in patients of cervical cancer from Maharashtra and to evaluate their association with risk of cervical cancer. Materials and Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to examine gene polymorphisms in 350 patients with cancer of cervix and 400 age and sex matched normal controls. Results: The results obtained indicated that there was no significant difference in the genotype distribution between cervical cancer patients and controls for XPC Lys939Gln, -371promoter and XPG His 1104 Asp. The result showed that genotype frequencies of XPC Val 499 Arg of codon 499 in exon 15 (OR=4.26; 95% CI= (3.007-6.03); p= <0.0001) were increased significantly. Conclusion: This study indicates that polymorphisms in Val499Arg haplotype of XPC gene appear to influence genetic susceptibility of individual to cervical cancer in Maharashtrian patients.
- Subjects
INDIA; CERVICAL cancer; CANCER genetics
- Publication
Journal of Krishna Institute of Medical Sciences (JKIMSU), 2018, Vol 7, Issue 4, p54
- ISSN
2231-4261
- Publication type
Article