We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigation of Serum Seladin-1/DHCR24 Levels in Breast Cancer Patients.
- Authors
Onmez, Attila; Esbah, Onur; Sahin, Ibrahim Ethem
- Abstract
Objective: Seladin-1, an enzyme that catalyzes the cholesterol formation reaction from desmosterol, has been shown to be expressed at different levels in various types of tumor. The purpose of this study was to investigate the relationship between serum seladin-1 levels and clinical characteristics of patients with non-metastatic breast cancer, and to examine the prognostic value of seladin-1 in breast cancer. Methods: Patients aged 18 and over diagnosed with breast cancer using histopathological methods at our medical oncology clinic, whose tumor tissue had been surgically removed and who had not yet received any oncological treatment, and with no distant organ metastasis or additional malignancy, and healthy women volunteers as a control group were included in the study. Demographic and laboratory data were recorded. Serum seladin-1 levels were compared between the patient and control groups. Results: Seventy-three women, 46 patients and 27 controls, were enrolled. Mean ages were 56±12 years in the patient group and 62±12 in the control group (p=0.055) Seladin-1 levels were lower in the patient group than in the control group (p=0.038). No statistically significant relationship was observed between tumor size and seladin- 1 levels (p=0.138). No relationship was also determined between patient grades and stages and seladin-1 (p=0.720; p=0.092, respectively). Conclusions: Seladin-1 levels were lower in the serum of breast cancer patients than in the control group. However, no statistically significant relationship was found between breast cancer prognostic factors and seladin-1 levels. Further research is needed to clarify the mechanisms underlying the low seladin-1 levels in breast cancer patients.
- Subjects
TURKEY; BREAST cancer prognosis; NERVE tissue proteins; METASTASIS; GENE expression; CANCER patients; ENZYMES; TUMOR markers; STATISTICAL correlation; BREAST tumors; SYMPTOMS
- Publication
Konuralp Medical Journal / Konuralp Tip Dergisi, 2021, Vol 13, Issue 1, p519
- ISSN
1309-3878
- Publication type
Article
- DOI
10.18521/ktd.785524