We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serous Carcinoma of the Uterine Cervix, an Extremely Rare Aggressive Entity: A Literature Review.
- Authors
Jonska-Gmyrek, Joanna; Zolciak-Siwinska, Agnieszka; Gmyrek, Leszek; Michalski, Wojciech; Poniatowska, Grazyna; Fuksiewicz, Malgorzata; Wiechno, Pawel; Kucharz, Jakub; Kowalska, Maria; Kotowicz, Beata
- Abstract
<bold>Background/aims: </bold>Serous carcinoma of the uterine cervix (USCC) is an extremely rare subtype. To establish the treatment strategy in patients with USCC is an important issue.<bold>Methods: </bold>MEDLINE (PubMed) was searched for all articles published after the first publication by Lurie et al. [Eur J Obstet Gynecol Reprod Biol 1991; 40: 79-81], reporting woman diagnosed with USCC. Because of limited numbers of studies on the topic of the study, we could not keep a restriction of eliminating smaller sample sizes.<bold>Results: </bold>A search of PubMed demonstrated that 113 cases of USCC have been reported in the literature since the first publication. The current treatment modality adopted for early cervical cancer is hysterectomy with bilateral iliac-obturator lymphadenectomy and postoperative radiotherapy (RT) or radiochemotherapy (RT-CT) if risk factors for cervical carcinoma appear. The treatment strategy for locally advanced USCC is preoperative RT-CT or chemotherapy (CHTH) with the intention to treat the patient surgically. The treatment option for disseminated disease is CHTH with paclitaxel and carboplatin.<bold>Conclusion: </bold>Risk factors and a more advanced clinical stage of USCC have an impact on poor outcomes despite the use of standard treatment methods, adapted for cervical cancer. The outside-pelvic failures tend to seek effective systemic treatment.
- Subjects
CERVICAL cancer treatment; CERVICAL cancer patients; HYSTERECTOMY; PACLITAXEL; CARBOPLATIN; THERAPEUTICS; ANTINEOPLASTIC agents; CANCER treatment; TUMOR treatment; CANCER; COMBINED modality therapy; SURGICAL excision; LYMPH node surgery; TUMORS; TUMOR classification; CERVIX uteri tumors; SYSTEMATIC reviews; TREATMENT effectiveness
- Publication
Gynecologic & Obstetric Investigation, 2018, Vol 83, Issue 3, p220
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000486675