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- Title
Natural polymers: Best carriers for improving bioavailability of poorly water soluble drugs in solid dispersions.
- Authors
Sapkal, Sandip; Narkhede, Mahesh; Babhulkar, Mukesh; Mehetre, Gautam; Rathi, Ashish
- Abstract
Natural polymers and its modified forms can be used as best alternative for improving bioavailability of poorly water soluble drugs in solid dispersion. Most of the natural polymers are hydrophilic and having high swelling capacity. Recent trend towards the use of natural polymer demands the replacement of synthetic additives with natural ones. Many plant derived natural polymers are studied for use in solid dispersion systems, out of which natural gums, cyclodextrin and carbohydrate are most extensively studied and used. This review discusses about the majority of these natural polymers, its uses and some recent investigations about modification of natural polymer in solid dispersion systems.
- Subjects
BIOPOLYMERS; BIOAVAILABILITY; DRUG solubility; DISPERSION (Chemistry); HYDROPHILIC compounds; CYCLODEXTRINS; CARBOHYDRATES
- Publication
Marmara Pharmaceutical Journal, 2013, Vol 17, Issue 2, p65
- ISSN
1309-0801
- Publication type
Article