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- Title
Differential Association Between HDL Subclasses and the Development of Type 2 Diabetes in a Prospective Study of Japanese Americans.
- Authors
You-Cheol Hwang; Tomoshige Hayashi; Fujimoto, Wilfred Y.; Kahn, Steven E.; Leonetti, Donna L.; McNeely, Marguerite J.; Boyko, Edward J.; Hwang, You-Cheol; Hayashi, Tomoshige
- Abstract
<bold>Objective: </bold>Recent studies have suggested that HDL cholesterol is inversely associated with the development of type 2 diabetes. However, little is known about the association between different HDL subclasses and the risk for future type 2 diabetes.<bold>Research Design and Methods: </bold>The study enrolled 406 Japanese Americans (51% male) without diabetes, aged 34-75 years. Oral glucose tolerance tests were performed to determine type 2 diabetes status at baseline, 2.5 years, 5 years, and 10 years after enrollment. HDL2, HDL3, total HDL cholesterol, and visceral adipose tissue (VAT) area by computed tomography were measured at baseline.<bold>Results: </bold>In univariate analysis, total HDL and HDL2 cholesterol were inversely associated with the incidence of type 2 diabetes, but HDL3 cholesterol was not. In multivariate analysis, total HDL cholesterol (odds ratio per 1-SD increment, 0.72 [95% CI 0.52-0.995], P = 0.047) and HDL2 cholesterol (odds ratio per 1-SD increment, 0.64 [95% CI 0.44-0.93], P = 0.018) were inversely associated with the risk for type 2 diabetes independent of age, sex, BMI, waist circumference, family history of diabetes, lifestyle factors, systolic blood pressure, lipid-lowering medication use, triglyceride level, HOMA-insulin resistance, and 2-h glucose; however, HDL3 cholesterol was not associated with diabetes risk. The association between diabetes risk and total HDL and HDL2 cholesterol became insignificant after adjustment for VAT area.<bold>Conclusions: </bold>Subjects with higher HDL2 cholesterol were at lower risk for incident type 2 diabetes, but this association was confounded by and not independent of VAT. Higher HDL3 cholesterol was not associated with diabetes risk.
- Subjects
HIGH density lipoproteins; JAPANESE Americans; TYPE 2 diabetes risk factors; GLUCOSE tolerance tests; CHOLESTEROL in the body; LONGITUDINAL method; DISEASES; HDL cholesterol; TYPE 2 diabetes; RESEARCH funding; ADIPOSE tissues
- Publication
Diabetes Care, 2015, Vol 38, Issue 11, p2100
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc15-0625