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- Title
Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007-2009.
- Authors
Ladhani, Shamez N.; Lucidarme, Jay; Newbold, Lynne S.; Gray, Stephen J.; Carr, Anthony D.; Findlow, Jamie; Ramsay, Mary E.; Kaczmarski, Edward B.; Borrow, Raymond
- Abstract
Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
- Subjects
ENGLAND; WALES; NEISSERIA meningitidis; DISEASE prevalence; EMERGING infectious diseases; PUBLIC health
- Publication
Emerging Infectious Diseases, 2012, Vol 18, Issue 1, p63
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1801.110901