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- Title
Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice.
- Authors
Fu, Huiying; Jin, Lu; Shao, Xia; Li, Yuanyuan; Chen, Fangming; Shou, Zhiqiang; Tang, Xiaofang; Ji, Bing; Shou, Qiyang
- Abstract
Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8+ T cells. In addition, HSF also ameliorated the immune-suppressive microenvironment and decreased the proportions of regulatory T cell and myeloid-derived suppressor cell populations. To confirm the effects of HSF on promotion of effector CD8+ T-cell production, we further evaluated changes in postoperative metastasis following treatment with HSF. Indeed, orthotopic lung metastasis was significantly suppressed, and survival times were increased in HSF-treated mice. Taken together, our findings suggested that HSF inhibited Lewis lung cancer by enhancing the population of effective CD8+ T cells.
- Subjects
FUNGI classification; CHINESE medicine; ANIMAL experimentation; BREAST tumors; FLOW cytometry; HERBAL medicine; HISTOLOGY; LUNG tumors; METASTASIS; MICE; RESEARCH funding; T cells; T-test (Statistics); DATA analysis software
- Publication
American Journal of Chinese Medicine, 2018, Vol 46, Issue 4, p911
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X18500489