We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
N-terminal pro-brain natriuretic peptide is a biomarker for cardiovascular damage in systemic lupus erythematous: a cross-sectional study.
- Authors
Sacre, Karim; Vinet, Evelyne; Pineau, Christian A; Mendel, Arielle; Kalache, Fares; Grenier, Louis-Pierre; Huynh, Thao; Bernatsky, Sasha
- Abstract
Objectives Prediction models based on traditional risk factors underestimate cardiovascular (CV) risk in systemic lupus erythematosus (SLE). In a large sample of unselected SLE patients, we investigated cross-sectional associations of NT-proBNP with cardiovascular damage (CVD). Methods Serum NT-proBNP was measured in SLE patients enrolled in the MUHC Lupus Clinic registry. Serum was collected between March 2022 and April 2023 at annual research visits. The primary outcome was CVD identified on the SLICC Damage Index. Factors associated with CVD and NT-proBNP levels were determined. Results Overall, 270 SLE patients [female 91%, median age 50.7 (first quartile to third quartile: 39.6–62.1) years] were analysed for the primary outcome. Among them, 33 (12%) had CVD. The ROC curve for NT - proBNP demonstrated strong associations with CVD (AUC 0.78, 95% CI 0.69–0.87) with a threshold of 133 pg/ml providing the best discrimination for those with/without CVD. Hypertension (OR 3.3, 95% CI 1.2–9.0), dyslipidaemia (OR 3.6, 95% CI 1.3–9.6) and NT-proBNP >133 pg/ml (OR 7.0, 95% CI, 2.6–19.1) were associated with CVD in the multivariable logistic regression model. Increased NT-proBNP levels were associated with age (OR 4.2, 95% CI 2.2–8.3), ever smoking (OR 1.9, 95% CI 1.0–3.5), reduced eGFR (4.1, 95% CI 1.3–13.1), prior pericarditis/pleuritis (OR 2.5, 95% CI 1.4–4.5) and aPL antibodies (OR 2.6, 95% CI 1.4–4.9). Conclusion NT-proBNP is a biomarker for CV damage in SLE. The novel associations of NT-proBNP levels with prior pericarditis/pleuritis and aPL antibodies suggest new avenues for research to better understand what drives CV risk in SLE.
- Subjects
RISK assessment; CROSS-sectional method; CARDIOVASCULAR diseases; PREDICTION models; RESEARCH funding; RECEIVER operating characteristic curves; HYPERLIPIDEMIA; HYPERTENSION; MULTIPLE regression analysis; SMOKING; PEPTIDE hormones; SYSTEMIC lupus erythematosus; CARDIOVASCULAR diseases risk factors; PERICARDITIS; ODDS ratio; CONFIDENCE intervals; BIOMARKERS
- Publication
Rheumatology, 2024, Vol 63, Issue 6, p1739
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kead522