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- Title
Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk.
- Authors
Katherine D. Crew; Marilie D. Gammon; Mary Beth Terry; Fang Fang Zhang; Meenakshi Agrawal; Sybil M. Eng; Sharon K. Sagiv; Susan L. Teitelbaum; Alfred I. Neugut; Regina M. Santella
- Abstract
FAS and FAS ligand (FASL) play key roles in apoptotic signaling and down-regulation of this pathway may facilitate tumorigenesis. Alterations in apoptosis genes may affect cancer risk by influencing individual susceptibility to environmental carcinogens. Using a population-based breast cancer caseâcontrol study on Long Island, New York, we examined whether polymorphisms in FAS and FASL modified the association between breast cancer risk and a marker of environmental exposures, polycyclic aromatic hydrocarbon (PAH)âDNA adducts. We examined polymorphisms in FAS (5â² UTR â1377G/A and 5â² UTR â670G/A) and FASL (5â² UTR â844C/T) in 1053 breast cancer cases and 1102 population-based controls. There was no significant association between these genetic polymorphisms and breast cancer risk. The presence of at least one variant allele (GA or AA) in FAS1377 was associated with a 36% increase in breast cancer risk among those with detectable PAHâDNA adduct levels [odds ratio (OR)â=â1.36, 95% confidence interval (CI)â=â1.01â1.83]. In addition, lactation history significantly modified the association between FAS1377 and FAS670 genetic variants and breast cancer risk (ORâ=â1.46, 95% CIâ=â1.04â2.06 and ORâ=â1.71, 95% CI =â1.13â1.58, respectively, in those who ever lactated compared with those who did not with the wild-type alleles). Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in the FAS gene and detectable PAHâDNA adducts.
- Subjects
APOPTOSIS; GENETIC polymorphisms; BREAST cancer; HEALTH risk assessment
- Publication
Carcinogenesis, 2007, Vol 28, Issue 12, p2548
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgm211