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- Title
Lymphotoxin-β regulates periderm differentiation during embryonic skin development.
- Authors
Cui, Chang-Yi; Kunisada, Makoto; Esibizione, Diana; Grivennikov, Sergei I.; Piao, Yulan; Nedospasov, Sergei A.; Schlessinger, David
- Abstract
Lymphotoxin-β (LTβ) is a key regulator of immune system development, but also affects late stages in hair development. In addition, high expression of LTβ at an early stage in epidermis hinted at a further function in hair follicle induction or epithelial development. We report that hair follicles were normally induced in LTβ−/− skin, but the periderm detached from the epidermis earlier, accompanied by premature appearance of keratohyalin granules. Expression profiling revealed dramatic down-regulation of a gene cluster encoding periderm-specific keratin-associated protein 13 and four novel paralogs in LTβ−/− skin prior to periderm detachment. Epidermal differentiation markers, including small proline-rich proteins, filaggrins and several keratins, were also affected, but transiently in LTβ−/− skin at the time of abnormal periderm detachment. As expected, Tabby mice, which lack the EDA gene, the putative upstream regulator of LTβ in skin, showed similar though milder periderm histopathology and alterations in gene expression. Overall, LTβ shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation.
- Publication
Human Molecular Genetics, 2007, Vol 16, Issue 21, p2583
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddm210