We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In vitro activity of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Trichosporon asahii.
- Authors
Silva de Loreto, Érico; Weiblen, Carla; Oliveira, Vanessa; Morais Santurio, Janio; Hartz Alves, Sydney; Felli Kubiça, Thaís; Bedin Denardi, Laura; Zeni, Gilson
- Abstract
Summary: This study evaluated the in vitro susceptibility of Trichosporon asahii strains to diphenyl diselenide (DPDS) and ebselen (EBS) alone and in combination with amphotericin B (AMB), fluconazole (FCZ), itraconazole (ITZ) and caspofungin (CAS) using the microdilution method. EBS showed in vitro activity against T asahii strains with minimal inhibitory concentration (MIC) ranged from 0.25 to 8.0 μg/mL. For DPDS, the MIC ranged from 8.0 to 64 μg/mL. The combinations demonstrating the greatest synergism rate against fluconazole‐resistant T asahii strains were the following: CAS + DPDS (96.67%), AMB + DPDS (93.33%), FCZ + DPDS (86.67%) and ITZ + DPDS (83.33%). The combinations AMB + DPDS and AMB + EBS exhibited the highest synergism rate against the fluconazole‐susceptible (FS) T asahii strains (90%). Antagonism was observed in the following combinations: FCZ + EBS (80%) and FCZ + DPDS (13.33%) against the FS strains, and ITZ + EBS (20%) against the FR strains. Our findings suggest that the antimicrobial activity of DPDS and EBS against T. asahii and its use as an adjuvant therapy with antifungal agents warrant in vivo experimental investigation.
- Subjects
TRICHOSPORON; ANTIFUNGAL agents; DIPHENYL diselenide; FLUCONAZOLE; DRUG resistance; EBSELEN
- Publication
Mycoses, 2019, Vol 62, Issue 5, p428
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12906