We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimycotic nail polish based on humic acid‐coated silver nanoparticles for onychomycosis.
- Authors
Dantas, Ketheleen N M; Andrade, Lucas R; Lisboa, Erika; Santana, Victoria L; Santos, André L S; Mello, Thaís P; Sangenito, Leandro S; Lima, Álvaro S; Fricks, Alini T; Begnami, Andreza F; Cano, Amanda; Zielinska, Aleksandra; Soares, Cleide M F; Souto, Eliana B; Severino, Patrícia
- Abstract
BACKGROUND The objective of this work was the development of silver nanoparticles (AgNPs) coated with humic acid (HA) and their incorporation into an enamel for antifungal activity. AgNPs were synthesized by chemical reduction using sodium borohydride as a reducing agent and coated with HA. Uncoated AgNPs were synthesized as control. AgNPs and HA‐AgNPs were characterized by ultraviolet–visible spectrophotometry, differential scanning calorimetry, dynamic light scattering, Fourier‐transform infrared spectroscopy (FTIR), atomic force microscopy and X‐ray diffraction (XRD). Size of AgNPs and HA‐AgNPs was recorded within the nano range, showing HA‐AgNPs' higher stability than non‐coated particles by presenting a single plasmatic band around 400 nm. RESULTS: Thermal analysis showed conjugated endothermic peaks, which confirms the compatibility of HA‐AgNPs. FTIR depicted absorptions between 1300 and 1000 cm−1 (CC, ArH, respectively), demonstrating that HA is adsorbed onto AgNPs. Thermogravimetric analysis showed that HA does not alter the reduction in mass loss of AgNPs, while it was found by XRD that adding HA promoted the formation of more amorphous AgNPs. The effectiveness of HA‐AgNPs was evaluated against three different fungal species. Minimum inhibitory concentration assays showed that ~0.5 mmol L−1 AgNPs was able to inhibit dermatophyte species growth. HA‐AgNPs were incorporated into a commercial enamel at a concentration of 8% and their organoleptic characteristics, drying time, centrifugation test and thermal stress were evaluated. Enamels with AgNPs kept their physicochemical properties over 21 days of storage. CONCLUSION: HA‐AgNP nail polish is thus proposed as an innovative material for onychomycosis infections. © 2021 Society of Chemical Industry
- Subjects
SOCIETY of Chemical Industry (Great Britain); NAIL polish; ONYCHOMYCOSIS; ATOMIC force microscopy; DIFFERENTIAL scanning calorimetry; HUMIC acid; LIGHT scattering; SILVER nanoparticles
- Publication
Journal of Chemical Technology & Biotechnology, 2021, Vol 96, Issue 8, p2208
- ISSN
0268-2575
- Publication type
Article
- DOI
10.1002/jctb.6676