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- Title
The structure characterization and biological activities of new polysaccharides from Armillariella tabescens (AT-P) and Tricholoma portentosum (TP-P).
- Authors
Zhou, Liqian; Ding, Xiang; Hou, Yiling
- Abstract
Polysaccharide is one of the four fundamental substances that make up life and have various important biological activities. A deep understanding of the structure and activity of polysaccharide molecules is of guiding significance for the development of polysaccharides. The structure characterization of two new polysaccharides from Armillariella tabescens (AT-P) and Tricholoma portentosum (TP-P) by HPGPC, GC-MS, NMR and FT-IR indicated that AT-P was composed of glucose and galactose in a ratio of 3:8. Its skeleton structure was consisted of (1→6)-galactose residues and (1→3,6)-galactose residues with three branched chains. The TP-P was consisted of composed of rhamnose, xylose, glucose, galactose in the ratio of 1:1:2:9. Its skeleton structure was consisted of (1→4)-galactose residues, (1→4)-glucose residues and (1→2,6)-galactose residues with one branched chain. Within the concentration range of 1.25 and 40 µg/mL, both AT-P and TP-P could enhance the proliferation ability of T cells, B cells, and RAW 264.7 cells. AT-P and TP-P could significantly (P < 0.01) improve the proliferation efficiency of B cells at 20 µg/mL and 10 µg/mL, respectively, with a maximum of 70.16% and 76.28%, respectively. Both AT-P and TP-P could promote the secretion of IL-1β and TNF-α by RAW 264.7 cells and promote the secretion of IL-1 by B and T cells. However, neither of they could not promote the secretion of IL-10 by RAW 264.7 cells and T cells. Their effects on the secretion of TNF-α by T and B cells were also different.
- Subjects
MORPHOLOGY; POLYSACCHARIDES; T cells; B cells; SECRETION; RHAMNOSE; INTERLEUKIN-1; GALACTOSE
- Publication
Journal of Food Measurement & Characterization, 2024, Vol 18, Issue 6, p4620
- ISSN
2193-4126
- Publication type
Article
- DOI
10.1007/s11694-024-02519-5