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- Title
Identification and treatment of APS renal involvement.
- Authors
Tektonidou, MG
- Abstract
Renal involvement in antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-related APS, includes renal artery stenosis or thrombosis, renal infarction, renal vein thrombosis and a small-vessel vaso-occlusive nephropathy defined as “antiphospholipid antibody (aPL)-associated nephropathy.” aPL-associated nephropathy is characterized by acute lesions, thrombotic microangiopathy, and chronic lesions such as fibrous intimal hyperplasia, organizing thrombi with or without recanalization, fibrous occlusions of arteries or arterioles and focal cortical atrophy. Systemic hypertension, hematuria, proteinuria (ranging from mild to nephrotic level) and renal insufficiency represent the major clinical manifestations associated with aPL-associated nephropathy. Similar renal histologic and clinical characteristics have been described among all different groups of patients with positive aPL (primary APS, SLE-related APS, catastrophic APS and SLE/non-APS with positive aPL). In patients with aPL-associated nephropathy lesions in the absence of other causes associated with similar histological characteristics, aPL testing needs to be considered.
- Subjects
ANTIPHOSPHOLIPID syndrome treatment; ANTIPHOSPHOLIPID syndrome; HEPATIC manifestations of general diseases; ETIOLOGY of kidney diseases; ARTERIAL stenosis; PHOSPHOLIPID antibodies; HEALTH outcome assessment; DIAGNOSIS
- Publication
Lupus, 2014, Vol 23, Issue 12, p1276
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1177/0961203314538687