We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques.
- Authors
Newman, Christina M.; Dudley, Dawn M.; Aliota, Matthew T.; Weiler, Andrea M.; Barry, Gabrielle L.; Mohns, Mariel S.; Breitbach, Meghan E.; Stewart, Laurel M.; Buechler, Connor R.; Graham, Michael E.; Post, Jennifer; Schultz-Darken, Nancy; Peterson, Eric; Newton, Wendy; Mohr, Emma L.; Capuano III, Saverio; O’Connor, David H.; Friedrich, Thomas C.
- Abstract
Zika virus is present in urine, saliva, tears, and breast milk, but the transmission risk associated with these body fluids is currently unknown. Here we evaluate the risk of Zika virus transmission through mucosal contact in rhesus macaques. Application of high-dose Zika virus directly to the tonsils of three rhesus macaques results in detectable plasma viremia in all animals by 2 days post-exposure; virus replication kinetics are similar to those observed in animals infected subcutaneously. Three additional macaques inoculated subcutaneously with Zika virus served as saliva donors to assess the transmission risk from contact with oral secretions from an infected individual. Seven naive animals repeatedly exposed to donor saliva via the conjunctivae, tonsils, or nostrils did not become infected. Our results suggest that there is a risk of Zika virus transmission via the mucosal route, but that the risk posed by oral secretions from individuals with a typical course of Zika virus infection is low.
- Publication
Nature Communications, 2017, Vol 8, Issue 8, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-00246-8