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- Title
EFFECT OF JAK/STAT-PPARG RECEPTOR MODULATOR IN INTRACEREBRAL PENDUNCLE ETHIDIUM BROMIDE INDUCED EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS IN RATS.
- Authors
Nitish; Sidharth, Mehan
- Abstract
Multiple sclerosis is an idiopathic and autoimmune associated motor neuron disorder that attacks myelinated neurons in specific brain regions of age group 20-40 years, where females are more prone to multiple sclerosis. In the pathogenesis of multiple sclerosis myeloid cells and pathogenic T helper cell are involved. Various cytokines used JAK/STAT pathway for signaling and in development, regulation and termination of immune response. Thus in the pathology of neuroinflammatory disease, dysregulation of the JAK/STAT pathway has a major factor. Many cytokines like IL-6, IL-12, IL-23, INF-γ are involved in multiple sclerosis and uses the JAK/STAT pathway to generate biological responses. Thus in the implications of multiple sclerosis and autoimmune inflammation of brain can be overcome by targeting the JAK/STAT.
- Subjects
MULTIPLE sclerosis; T helper cells; IMMUNOREGULATION; NATALIZUMAB; MOTOR neurons; ENCEPHALITIS
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p52
- ISSN
0976-7126
- Publication type
Article