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- Title
Separation and Detection of Smokeless Powder Additives by Ultra Performance Liquid Chromatography with Tandem Mass Spectrometry ( UPLC/ MS/ MS)<sup>,</sup> Separation and Detection of Smokeless Powder Additives by Ultra Performance Liquid Chromatography with Tandem Mass Spectrometry ( UPLC/ MS/ MS)
- Authors
Thomas, Jennifer L.; Lincoln, Danielle; McCord, Bruce R.
- Abstract
A reversed phase gradient ultra performance liquid chromatography tandem mass spectrometry (UPLC/MS/MS) method has been developed for the analysis of smokeless powders. A total of 20 different components were separated by UPLC and detected by MS/ MS in multiple reaction monitoring (MRM) mode. These compounds included diphenylamines, centralites, nitrotoluenes, nitroglycerin, and various phthalates. Simultaneous positive and negative electrospray ionization ( ESI) was used along with negative atmospheric pressure chemical ionization ( APCI) to detect all compounds in a single analysis. Analysis times were under 8 min with a gradient of 10-73% organic at a flow rate of 0.500 mL/min. With this method, ultraviolet and MRM limits of detection ranging from 0.08 to 2.6 ng and 0.4-64 ng injected were achieved. Commercially available smokeless powders were also extracted with methylene chloride and characterized using the developed UPLC/ MS/ MS method. The procedure permits the determination of compositional differences between different brands as well as lot-to-lot variations.
- Subjects
SMOKELESS powder; TANDEM mass spectrometry; DIPHENYLAMINE; NITROTOLUENE; NITROGLYCERIN; PHTHALATE esters; ELECTROSPRAY ionization mass spectrometry; CHEMICAL ionization mass spectrometry
- Publication
Journal of Forensic Sciences, 2013, Vol 58, Issue 3, p609
- ISSN
0022-1198
- Publication type
Article
- DOI
10.1111/1556-4029.12096