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- Title
3-(IMIDAZOL-1-YL)PROPANE-1,2-DIOL AND 3-(1,2,4-TRIAZOL-1-YL)PROPANE-1,2-DIOL: SYNTHESIS AND THEIR TRANSFORMATION TO BIOACTIVE CYCLIC KETALS.
- Authors
Talismanov, V. S.; Popkov, S. V.; Karmanova, O. G.; Zykova, S. S.; Shustov, M. V.; Zhuravleva, L. A.; Tokareva, N. G.
- Abstract
3-(Imidazol-1-yl)propane-1,2-diol and 3-(1,2,4-triazol-1-yl)propane-1,2-diol were obtained by three alternative synthetic pathways such as hydrolysis of 1-[(1,3-dioxolan-4-yl)methyl]-azoles, Wagner reaction of N-allylazoles and reaction of glycidol with imidazole or 1,2,4-triazole. The 4-(azol-1-ylmethyl)-1,3-dioxolanes can be synthesized by reaction of 3-(imidazol-1-yl)propane-1,2-diol or 3-(1,2,4-triazol-1-yl)propane-1,2-diol with ketones to substituted 4-azolylmethyl-1,3-dioxolanes
- Subjects
KETALS; KETONES; HYDROLYSIS; IMIDAZOLES; GLYCOLS
- Publication
Rasayan Journal of Chemistry, 2021, Vol 14, Issue 3, p1711
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2021.1436537