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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
Published in:
Biochemical Journal, 2012, v. 448, n. 1, p. 67, doi. 10.1042/BJ20121014
By:
- MORGAN, Hugh P.;
- WALSH, Martin J.;
- BLACKBURN, Elizabeth A.;
- WEAR, Martin A.;
- BOXER, Matthew B.;
- SHEN, Min;
- VEITH, Henrike;
- MCNAE, Iain W.;
- NOWICKI, Matthew W.;
- MICHELS, Paul A. M.;
- AULD, Douglas S.;
- FOTHERGILL-GILMORE, Linda A.;
- WALKINSHAW, Malcolm D.
Publication type:
Article
Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Published in:
Nature Communications, 2016, v. 7, n. 2, p. 10649, doi. 10.1038/ncomms10649
By:
- Kenny, Hilary A.;
- Lal-Nag, Madhu;
- White, Erin A.;
- Shen, Min;
- Chiang, Chun-Yi;
- Mitra, Anirban K.;
- Zhang, Yilin;
- Curtis, Marion;
- Schryver, Elizabeth M.;
- Bettis, Sam;
- Jadhav, Ajit;
- Boxer, Matthew B.;
- Li, Zhuyin;
- Ferrer, Marc;
- Lengyel, Ernst
Publication type:
Article
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Published in:
Nature Communications, 2015, v. 6, n. 2, p. 6220, doi. 10.1038/ncomms7220
By:
- Kenny, Hilary A.;
- Lal-Nag, Madhu;
- White, Erin A.;
- Shen, Min;
- Chiang, Chun-Yi;
- Mitra, Anirban K.;
- Zhang, Yilin;
- Curtis, Marion;
- Schryver, Elizabeth M.;
- Bettis, Sam;
- Jadhav, Ajit;
- Boxer, Matthew B.;
- Li, Zhuyin;
- Ferrer, Marc;
- Lengyel, Ernst
Publication type:
Article
Discovery of novel inhibitors of human galactokinase by virtual screening.
Published in:
Journal of Computer-Aided Molecular Design, 2019, v. 33, n. 4, p. 405, doi. 10.1007/s10822-019-00190-3
By:
- Hu, Xin;
- Zhang, Ya-Qin;
- Lee, Olivia W.;
- Liu, Li;
- Tang, Manshu;
- Lai, Kent;
- Boxer, Matthew B.;
- Hall, Matthew D.;
- Shen, Min
Publication type:
Article
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Published in:
Nature, 2015, v. 522, n. 7555, p. 216, doi. 10.1038/nature14335
By:
- Najm, Fadi J.;
- Madhavan, Mayur;
- Zaremba, Anita;
- Shick, Elizabeth;
- Karl, Robert T.;
- Factor, Daniel C.;
- Miller, Tyler E.;
- Nevin, Zachary S.;
- Kantor, Christopher;
- Sargent, Alex;
- Quick, Kevin L.;
- Schlatzer, Daniela M.;
- Tang, Hong;
- Papoian, Ruben;
- Brimacombe, Kyle R.;
- Shen, Min;
- Boxer, Matthew B.;
- Jadhav, Ajit;
- Robinson, Andrew P.;
- Podojil, Joseph R.
Publication type:
Article
The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
Published in:
Science Translational Medicine, 2021, v. 13, n. 607, p. 1, doi. 10.1126/scitranslmed.abd3904
By:
- Caffall, Zachary F.;
- Wilkes, Bradley J.;
- Hernández-Martinez, Ricardo;
- Rittiner, Joseph E.;
- Fox, Jennifer T.;
- Wan, Kanny K.;
- Shipman, Miranda K.;
- Titus, Steven A.;
- Zhang, Ya-Qin;
- Patnaik, Samarjit;
- Hall, Matthew D.;
- Boxer, Matthew B.;
- Shen, Min;
- Li, Zhuyin;
- Vaillancourt, David E.;
- Calakos, Nicole
Publication type:
Article
A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety.
Published in:
ChemMedChem, 2010, v. 5, n. 5, p. 730, doi. 10.1002/cmdc.200900531
By:
- Boxer, Matthew B.;
- Quinn, Amy M.;
- Shen, Min;
- Jadhav, Ajit;
- Leister, William;
- Simeonov, Anton;
- Auld, Douglas S.;
- Thomas, Craig J.
Publication type:
Article
Inside Cover: A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety (ChemMedChem 5/2010).
Published in:
ChemMedChem, 2010, v. 5, n. 5, p. 634, doi. 10.1002/cmdc.201090016
By:
- Boxer, Matthew B.;
- Quinn, Amy M.;
- Shen, Min;
- Jadhav, Ajit;
- Leister, William;
- Simeonov, Anton;
- Auld, Douglas S.;
- Thomas, Craig J.
Publication type:
Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Published in:
Nature Chemical Biology, 2012, v. 8, n. 12, p. 1008, doi. 10.1038/nchembio1212-1008b
By:
- Anastasiou, Dimitrios;
- Yu, Yimin;
- Israelsen, William J;
- Jiang, Jian-kang;
- Boxer, Matthew B;
- Hong, Bum Soo;
- Tempel, Wolfram;
- Dimov, Svetoslav;
- Shen, Min;
- Jha, Abhishek;
- Yang, Hua;
- Mattaini, Katherine R;
- Metallo, Christian M;
- Fiske, Brian P;
- Courtney, Kevin D;
- Malstrom, Scott;
- Khan, Tahsin M;
- Kung, Charles;
- Skoumbourdis, Amanda P;
- Veith, Henrike
Publication type:
Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Published in:
Nature Chemical Biology, 2012, v. 8, n. 10, p. 839, doi. 10.1038/nchembio.1060
By:
- Anastasiou, Dimitrios;
- Yu, Yimin;
- Israelsen, William J;
- Jiang, Jian-Kang;
- Boxer, Matthew B;
- Hong, Bum Soo;
- Tempel, Wolfram;
- Dimov, Svetoslav;
- Shen, Min;
- Jha, Abhishek;
- Yang, Hua;
- Mattaini, Katherine R;
- Metallo, Christian M;
- Fiske, Brian P;
- Courtney, Kevin D;
- Malstrom, Scott;
- Khan, Tahsin M;
- Kung, Charles;
- Skoumbourdis, Amanda P;
- Veith, Henrike
Publication type:
Article

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