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- Title
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
- Authors
Le Pichon, Claire E.; Meilandt, William J.; Dominguez, Sara; Solanoy, Hilda; Han Lin; Hai Ngu; Gogineni, Alvin; Ghosh, Arundhati Sengupta; Zhiyu Jiang; Seung-Hye Lee; Maloney, Janice; Gandham, Vineela D.; Pozniak, Christine D.; Bei Wang; Sebum Lee; Michael Siu; Patel, Snahel; Modrusan, Zora; Xingrong Liu; Rudhard, York
- Abstract
The article focuses on the role of dual leucine zipper kinase (DLK) as progressive neurodegeneration regulator in neurodegenerative diseases such as Alzheimer's disease and in amyotrophic lateral sclerosis. Topics include the genetic deletion in DLK, DLK/c-Jun N-terminal kinase signaling in mouse model, and the analysis of the pharmacological inhibition of DLK.
- Subjects
LEUCINE zippers; REGULATOR genes; NEURODEGENERATION; GENETICS of Alzheimer's disease; GENETICS of amyotrophic lateral sclerosis; PHARMACOLOGY; GENETICS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 403, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aag0394