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- Title
Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal.
- Authors
Jain, Chandni V.; Kadam, Leena; van Dijk, Marie; Kohan-Ghadr, Hamid-Reza; Kilburn, Brian A.; Hartman, Craig; Mazzorana, Vicki; Visser, Allerdien; Hertz, Michael; Bolnick, Alan D.; Fritz, Rani; Armant, D. Randall; Drewlo, Sascha
- Abstract
The article discusses a study on the diagnosis of birth defects of genetic origin in utero after invasive extraction of fetal tissues. The study performed noninvasive testing with circulating cell-free fetal DNA. It examined intact trophoblast cells from Papanicolaou smears collected from pregnant women and employed multiplex targeted DNA sequencing to profile matched maternal, placental and fetal samples.
- Subjects
HUMAN abnormality genetics; FETAL tissues; HUMAN abnormality etiology; TROPHOBLAST; PAP test; NUCLEOTIDE sequencing
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 363, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aah4661