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- Title
Plasmacytoid Dendritic Cells: From Heart to Vessels.
- Authors
Sorrentino, Rosalinda; Morello, Silvana; Pinto, Aldo
- Abstract
Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immunebased pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that down modulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches.
- Subjects
CARDIOVASCULAR diseases; DENDRITIC cells; T cells; PREVENTIVE medicine; PHENOTYPES; PATHOLOGY; CELLULAR immunity
- Publication
International Journal of Vascular Medicine, 2010, p1
- ISSN
2090-2824
- Publication type
Article
- DOI
10.1155/2010/430318