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- Title
Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls.
- Authors
Şimşek, Fulya; Işık, Ümit; Aktepe, Evrim; Kılıç, Faruk; Şirin, Fevziye Burcu; Bozkurt, Mustafa
- Abstract
The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1α levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4–12 years were included. Serum levels of VEGF, IGF-1, and HIF-1α were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1α levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1α may play a potential role in the etiopathogenesis of ASD.
- Subjects
SOMATOMEDIN; COMPARATIVE studies; SEVERITY of illness index; AUTISM; DNA-binding proteins; ENZYME-linked immunosorbent assay; VASCULAR endothelial growth factors; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2021, Vol 51, Issue 10, p3564
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-020-04820-w