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- Title
Chemical composition by HPLC-ESI-QTOF-MS/MS: Estrogenic and antioxidant effects of Mangifera indica L. cv. "Kent" leave extracts on ovariectomized rats.
- Authors
Benites, Julio; Asunción-Alvarez, Holbert D.; Ybañez-Julca, Roberto O.; Ganoza-Yupanqui, Mayar L.; Jacinto-Fernandez, Juan J.; la Vega, Junior B. Reyes-De; Zavaleta-Cruz, Hair J.; Pinedo-Alcántara, Adela N.; Lavado-Fonseca, Cristian M.; Medina-Mejia, Carlos A.; Catalan, Marcelo; Morales, Bernardo; de Albuquerque, Ricardo D. D. G.; Rocha, Leandro; Martinez, José L.
- Abstract
The chemical composition of Mangifera indica L. cv. "Kent" leaves was determined by HPLC-ESI-QTOF-MS/MS. Polyphenolic compounds characterized as benzophenone derivatives were the main components found in extracts (1, maclurin 3-C-(2-O-galloyl)-Dglucoside isomer; 2, maclurin 3-C---D-glucoside; 3, iriflophenone 3-C---D-glucoside; 5, maclurin 3-C-(2,3-di-O-galloyl)---D-glucoside; 6, iriflophenone 3-C-(2-O-galloyl)---D-glucoside; 7, methyl-iriflophenone 3-C-(2,6-di-O-galloyl)---D-glucoside) and xanthones (4, mangiferin and 8, 6-O-galloyl-mangiferin). The estrogenic and antioxidant effects of aqueous extracts from Mangifera indica L. cv. "Kent" leaves on ovariectomized rats were determined by uterotrophic assay and malondialdehyde (MDA) levels in erythrocytes, bone, liver, and stomach. We conclude that the polyphenolic compounds from extracts act as exogenous antioxidant agents against oxidative damage in ovariectomized rats.
- Subjects
MANGIFERA; RATS; EXTRACTS; ANTIOXIDANTS; XANTHONE; HYDROXYBENZOPHENONES; ISOMERS
- Publication
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2019, Vol 18, Issue 3, p336
- ISSN
0717-7917
- Publication type
Article