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- Title
Effect of propolis supplementation on glycemic indices and liver function in obese patients with NAFLD.
- Authors
Nikbaf-Shandiz, Mahlagha; Ebrahimi-Mamaghani, Mehrangiz
- Abstract
Objectives: As propolis has been reported to have several biological efficacies such as antioxidant and anti-inflammatory activities and insulin resistance is the most important hit in non-alcoholic fatty liver disease (NAFLD), the present study aimed to examine the effects of propolis supplementation on glycemic indices and liver function among obese patients with NAFLD. Methods: This double-blinded, placebocontrolled randomized clinical trial was carried out on 44 obese patients with NAFLD who were randomly assigned into two groups; "Propolis" (n=23) and "Placebo" (n=21). The patients received either 500 mg of propolis three time a day (1500 mg) or corn starch for 8 weeks associated with individual calorie-restricted diet. Fasting blood sugar (FBS), insulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and severity of NAFLD were measured at the beginning and end of the study and insulin resistance using HOMA-IR was estimated. The severity of hepatic steatosis was assessed using ultrasonography. Results: FBS, insulin, HOMA-IR significantly decreased in propolis group compared with placebo group (p < 0.05). There were significant reduction in serum ALT levels and NAFLD severity in both groups while serum AST levels significantly decreased only in propolis group. However, between-group differences were not statistically significant. Conclusion: our results indicate that propolis supplementation could be suggested as an adjuvant therapy in patients with NAFLD.
- Subjects
GLYCEMIC control; PROPOLIS; FATTY liver; LIVER function tests; DIETARY supplements; ANTI-inflammatory agents
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p270
- ISSN
2821-2746
- Publication type
Article