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- Title
Characteristics and Clinical Evolution of Patients with Acute Myeloblastic Leukemia in Northeast Mexico: An Eight-Year Experience at a University Hospital.
- Authors
Jaime-Pérez, José Carlos; Brito-Ramirez, Alma Sirenia; Pinzon-Uresti, Monica Andrea; Gutiérrez-Aguirre, Homero; Cantú-Rodríguez, Olga G.; Herrera-Garza, José Luis; Gomez-Almaguer, David
- Abstract
Background/Objective: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. We documented the characteristics and results of treatment of patients with AML at a single reference center. Methods: Patients diagnosed with AML between June 2003 and July 2011 at a university hospital in northeast Mexico were studied. Overall survival (OS) and event-free survival (EFS) were determined, and risk factors were analyzed with respect to their influence on prognosis. Results: A total of 132 AML patients were included. Median age was 32 years. Complete remission (CR) was achieved by 55% of patients. CR was achieved by 65.1% of patients <60 years (n = 109), compared to 8.7% of those >60 years (n = 23; p < 0.001). In all, 39% of patients >60 years suffered an early death, compared to 14.7% of those <60 years (p < 0.001). OS for patients with AML was 35%, whereas EFS was 32%. On multivariate analysis, patients >60 years had a lower OS and EFS (p < 0.001). A total of 28% of patients received a transplant, and they had higher OS and EFS. Conclusions: Our patients were considerably younger and had remarkably lower survival rates than reported for other populations; those >60 years had a higher early death rate, and fewer of these patients achieved CR. © 2014 S. Karger AG, Basel
- Subjects
ACUTE myeloid leukemia treatment; ACUTE myeloid leukemia; MEXICANS; MEDICAL statistics; CLINICAL trials; PROGNOSIS; DISEASES; DISEASE risk factors
- Publication
Acta Haematologica, 2014, Vol 132, Issue 2, p144
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000356794