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- Title
Primary Thyroid Marginal Zone B-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue Type: Clinical Manifestation and Outcome of a Rare Disease - Consortium for Improving Survival of Lymphoma Study.
- Authors
Oh, Sung Yong; Kim, Won Seog; Kim, Jin Seok; Kim, Seok Jin; Lee, Suee; Lee, Dae Ho; Kang, Hye Jin; Song, Moo Kon; Kim, Hyo Jung; Kwon, Jung Hye; Kwak, Jae-Yong; Park, Byeong-Bae; Do, Young-Rok; Jeong, Seong Hyun; Suh, Cheolwon
- Abstract
Purpose: Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established. Methods: A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed. Results: The median age of our subjects was 53 years (range 25-82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto's thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study. Conclusion: pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients' responses were sustained for a prolonged period. Copyright © 2011 S. Karger AG, Basel
- Subjects
B cell lymphoma; LYMPHOID tissue; LYMPHOMAS; BONE marrow cancer; THYROGLOBULIN; THYROIDITIS; TUMORS
- Publication
Acta Haematologica, 2012, Vol 127, Issue 2, p100
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000333113