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- Title
Phenobarbital-Associated Bone Marrow Aplasia: A Case Report and Review of the Literature.
- Authors
Focosi, Daniele; Kast, Richard Eric; Benedetti, Edoardo; Papineschi, Federico; Galimberti, Sara; Petrini, Mario
- Abstract
We report on a 22-year-old female who developed aplastic anemia after administration of phenobarbital for 6 years. Being refractory to steroid and anti-lymphocyte serum, the patient received allogeneic stem cell transplantation, achieving complete remission. We discuss here the potential mechanisms by which phenobarbital and other anti-epileptic drugs can cause aplastic anemia and review the literature for previous case reports and epidemiological studies. Copyright © 2008 S. Karger AG, Basel
- Subjects
CASE studies; APLASTIC anemia; BONE marrow diseases; STEM cell transplantation; ANTICONVULSANTS
- Publication
Acta Haematologica, 2008, Vol 119, Issue 1, p18
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000114096