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- Title
Impaired Postprandial Blood Flow in Adipose Tissue May Be an Early Marker of Insulin Resistance in Type 2 Diabetes.
- Authors
Dimitriadis, George; Lambadiari, Vaia; Mitrou, Panayota; Maratou, Eirini; Boutati, Eleni; Panagiotakos, Demosthenes B.; Economopoulos, Theofanis; Raptis, Sotirios A.
- Abstract
OBJECTIVE--We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes. RESEARCH DESIGN AND METHODS--Five groups were examined: healthy control subjects, first-degree relatives of subjects with type 2 diabetes, subjects with impaired glucose tolerance (IGT), subjects with type 2 diabetes and postprandial hyperglycemia but normal fasting plasma glucose levels (diabetes group A [DMA]), and subjects with type 2 diabetes with both postprandial and fasting hyperglycemia (diabetes group B [DMB]). ATBF was measured with 133Xe. RESULTS--ATBF was higher in control subjects (1,507±103 ml/100 cm³ tissue x min) versus relatives and IGT, DMA, and DMB subjects (845 ± 123,679 - 69,765±60, and 757 ± 69 ml/100 cm³ tissue x min, respectively; P < 0.001). Insulin sensitivity index (ISI) in control subjects (82 ± 3 mg x l²/mmol x mU x min) was higher versus that for relatives and IGT, DMA, and DMB subjects (60±3, 45 ± 1, 40 ± 6, and 29 ± 4 mg x l²/mmol x mU X min, respectively; P < 0.0001). ISI was positively associated with peak-baseline ATBF (β coefficient 0.029±0.013, P = 0.03). CONCLUSIONS--After meal ingestion, insulin-stimulated ATBF was decreased in relatives and and IGT, DMA, and DMB subjects. This defect could be an early marker of insulin resistance that precedes the development of type 2 diabetes.
- Subjects
BLOOD flow; ADIPOSE tissues; INSULIN resistance; TYPE 2 diabetes; DIABETES
- Publication
Diabetes Care, 2007, Vol 30, Issue 12, p3128
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc07-0699