We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyperthermia in the course of tetany in a child with Dent's disease - case report.
- Authors
Banaszak, Beata; Olejarz, Anna; Stobiecka, Martyna; Szczepańska, Maria
- Abstract
Tetany is a condition in which serum electrolyte disturbances lead to increased neuronal excitability. We describe a case of life-threatening tetany in a 2.5-year-old boy with Dent's disease linked with the CLCN5 gene. Dent's disease is a renal tubular disorder characterized by a proximal tubule defect resulting in low-weight proteinuria, hypercalciuria, phosphaturia, impaired urinary acidification, nephrolithiasis/nephrocalcinosis and progressive renal failure. In the presented patient, multiple electrolyte derangements in the form of hyponatremia, hypochloremia, hypokalemia, hypocalcemia, and hypomagnesemia, determined by Dent's disease, led to the development of diffuse muscle spasm and rhabdomyolysis, which ended with acute hyperthermia and seizures. Although, due to acuity of symptoms sepsis was suspected, the child showed dramatic improvement after the aggressive electrolyte repletion. We emphasize the need for considering tetany in patients with unstable vital signs, muscle cramping and medical conditions underlying electrolyte disorders.
- Subjects
TREATMENT of fever; THERAPEUTIC use of magnesium; FOREARM; INFANT formulas; FEVER; INTRAVENOUS therapy; DRINKING (Physiology); INFLAMMATION; ACETAMINOPHEN; ORAL drug administration; OXYGEN masks; TETANY; OXYGEN saturation; POTASSIUM; SEPSIS; RISK assessment; MUSCLE cramps; SUPRAVENTRICULAR tachycardia; HYPONATREMIA; HYPOCALCEMIA; CALF muscles; PROTEINURIA; ELECTROCARDIOGRAPHY; INBORN errors of metabolism; RENAL tubular transport disorders; SEIZURES (Medicine); HYPOKALEMIA; ENTERAL feeding; ELECTROLYTES; ANTIBIOTICS; DIAZEPAM; DISEASE risk factors; DISEASE complications; CHILDREN
- Publication
Polish Journal of Pediatrics / Pediatria Polska, 2023, Vol 98, Issue 4, p362
- ISSN
0031-3939
- Publication type
Article
- DOI
10.5114/polp.2023.133543