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- Title
Aumento del grosor íntima-media carotídeo y esteatosis hepática en pacientes pediátricos con obesidad y anormalidades metabólicas.
- Authors
Contreras-Vázquez C.; Rivera-Villanueva R.; Ruiz-Ochoa D.; Bocanegra-Kanagú A.; Millán-Sánchez N.; Moreno-Castillo E.; León-Hernández S.; Lugo-Álvarez I.
- Abstract
Ultrasound studies of the thickness of the carotid intima-media are gaining importance; the increase is associated with atherosclerosis in adults and in children, and with non-alcoholic steatosis. Objective: to determine the association between increased intima-media thickness and steatosis in pediatric patients with obesity and metabolic abnormalities. Material and methods: A transverse observational study of internal strata in children diagnosed with overweight and obesity 6 to 16 years of age; carotid intima-media thickness, steatosis, laboratory studies, and anthropometric parameters were evaluated. Results: A strong association was observed between steatosis and increased carotid intima-media thickness. Patient with moderate steatosis had 2.36 times greater risk of intima-media thickness of 0.6-0.8 mm. In general, the combination of means of six variables (weight, body mass index, fat mass, percentage of fat, cholesterol, and alanine aminotransferase) accurately classifies 82% of cases, with sensitivity of 97.4, 80, and 100% for intima-media thicknesses of 0.4-0.5, 0.7, and 0.8 mm, respectively; the accuracy drops to 40% for thicknesses of 0.6 mm. Independently of intima-media thickness, cases with moderate steatosis had low concentrations of HDL cholesterol. Conclusions: Weight, body mass index, fat mass, percentage of fat, cholesterol, and alanine aminotransferase are variables which help classify to which thickness group a child pertains; high values are related to higher risk of steatosis and low levels of HDL cholesterol.
- Publication
Anales de Radiologia, Mexico, 2015, Vol 14, Issue 4, p395
- ISSN
1665-2118
- Publication type
Article