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- Title
Synthesis of thermoresponsive polymeric micelles of PNIPAAm- b-OMMA as a drug carrier for loading and controlled release of prednisolone.
- Authors
Li, Wei; Tu, Weixia; Cao, Dapeng
- Abstract
The article examines the synthesis of a drug delivery system of poly(N-isopropylacrylamide)-b-oligo(methyl methacrylate) (PNIPAAm-b-OMMA) via polycondensation of two homopolymers in 1,4-dioxane. The PNIPAAm-b-OMMA copolymer micelles in aqueous solution exhibit the same lower critical solution temperature as the unmodified PNIPAAm, owing to the development of a core-shell micellar structure that the hydrophilic shell prevents the hydrophobic inner OMMA core from interacting with water.
- Subjects
MICELLES; POLYMERS; DRUG carriers; CONTROLLED release drugs; METHYL methacrylate; POLYCONDENSATION
- Publication
Journal of Applied Polymer Science, 2009, Vol 111, Issue 2, p701
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.29125