We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Opportunistic Infection-Associated Immune Reconstitution Syndrome in Transplant Recipients.
- Authors
Sun, Hsin-Yun; Singh, Nina
- Abstract
Reversal of pathogen-induced immunosuppression upon employment of effective antimicrobial therapy and withdrawal of iatrogenic immunosuppression has the potential to shift the host immune repertoire towards pathologic inflammatory responses conducive to immune reconstitution syndrome (IRS). Posttransplant IRS has been observed with fungi, M. tuberculosis, cytomegalovirus, and polyoma virus nephropathy. This review discusses the existing state of knowledge regarding IRS and the immune mechanisms that underlie its pathogenesis, with significant implications for developing reliable diagnostic biomarkers and optimal management strategies for post-transplant opportunistic infection-associated IRS.
- Subjects
PATHOGENIC microorganisms; IMMUNOSUPPRESSION; MYCOBACTERIUM tuberculosis; CYTOMEGALOVIRUSES; POLYOMAVIRUSES
- Publication
Clinical Infectious Diseases, 2011, Vol 53, Issue 2, p168
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cir276