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- Title
新疆地区人群非综合征型唇腭裂与外周血 FOXN3-SIN3A复合物表达量相关性研究.
- Authors
多力昆; 吾甫尔; 地丽拜尔; 依明江; 卡米力江; 买买提明; 李军; 乌丽凡; 托勒恒
- Abstract
Objective This work aimed to study the correlation between FOXN3-SIN3A complex expression and non-syndromic oral clefts (NSOC) in Xinjiang. Methods In this study, 60 patients with NSOC attending the People5 s Hospital of Xinjiang Uygur Autonomous Region were recruited into the case group, including 30 cleft lip with or without cleft palate (NSCL/P), 30 cleft palate only (CPO), and 30 healthy children in the control group. The expression levels of FOXN3, SIN3A, and NEAT1 in peripheral blood of each group were detected by high-throughput second-generation sequencing technology and quantitative reverse transcription polymerase chain reaction (RT-qPCR). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to analyze the diagnostic efficiency of NSOC. Results The comparison of the NSOC and control groups showed that FOXN3, SIN3A, and NEAT1 genes increased compared with the control group. The differences were all statistically significant (尸<0.05). The AUCs of FOXN3, SIN3A, and NEAT1 in the NSCL/P group were 0.933 [95%CI=(0.864, 1.000)], 0.822 [(95%CI=(0.713, 0.932)], and 1.000[95%CI= (1.000, 1.000)], respectively. The AUCs of FOX-N3, SIN3A, and NEAT1 in the CPO group were 0.891 [95%CI=(0.806, 0.976)], 0.688 [95%CI= (0.552, 0.824)], and 1.000 [95%CI=(1.000, 1.000)], respectively. Conclusion The results showed a correlation between the rising gene expression of FOXN3, SIN3A, and NEAT1 in peripheral blood and the occurrence of NSOC in Xinjiang. This work provides a theoretical basis for further study of the FOXN3-SIN3A complex as bioinarkers to facilitate the early screening, disease prediction, and early prevention of NSOC.
- Publication
West China Journal of Stomatology, 2024, Vol 42, Issue 3, p313
- ISSN
1000-1182
- Publication type
Article
- DOI
10.7518/hxkq.2024.2023340