We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom.
- Authors
PEBODY, R. G.; ANDREWS, N.; FLEMING, D. M.; McMENAMIN, J.; COTTRELL, S.; SMYTH, B.; DURNALL, H.; ROBERTSON, C.; CARMAN, W.; ELLIS, J.; SEBASTIAN-PILLAI, P.; ZAMBON, M.; KEARNS, C.; MOORE, C.; THOMAS, D. RH.; WATSON, J. M.
- Abstract
An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall TIV effectiveness, adjusted for age and month, against confirmed influenza A(H1N1)pdm 2009 infection was 56% (95% CI 42–66); age-specific adjusted VE was 87% (95% CI 45–97) in <5-year-olds and 84% (95% CI 27–97) in 5- to 14-year-olds. Adjusted VE for PIV was only 28% (95% CI −6 to 51) overall and 72% (95% CI 15–91) in <5-year-olds. For confirmed influenza B infection, TIV effectiveness was 57% (95% CI 42–68) and in 5- to 14-year-olds 75% (95% CI 32–91). TIV provided moderate protection against the main circulating strains in 2010/2011, with higher protection in children. PIV administered during the previous season provided residual protection after 1 year, particularly in the <5 years age group.
- Subjects
UNITED Kingdom; INFLUENZA vaccines; PANDEMICS; INFLUENZA prevention; MEDICAL consultants
- Publication
Epidemiology & Infection, 2013, Vol 141, Issue 3, p620
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268812001148