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- Title
The emerging strains of Shigella dysenteriae type 2 in Bangladesh are clonal.
- Authors
Talukder KA; Khajanchi BK; Islam MA; Dutta DK; Islam Z; Khan SI; Nair GB; Sack DA; Talukder, K A; Khajanchi, B K; Islam, M A; Dutta, D K; Islam, Z; Khan, S I; Nair, G B; Sack, D A
- Abstract
A total of 113 strains of Shigella dysenteriae type 2 isolated from patients attending the Dhaka diarrhoea treatment centre of ICDDR,B: Centre for Health and Population Research during the period 1999-2004 were studied. Serotype of the isolates was confirmed using commercially available antisera. Except for arabinose fermentation, all the strains had similar biochemical reactions. More than 60% of the strains were sensitive to commonly used antibiotics; only 6% (n=7) of the strains were resistant to nalidixic acid, and none of the strains were resistant to mecillinam and ciprofloxacin. All strains were invasive as demonstrated by the presence of a 140 MDa plasmid, ial, sen and ipaH genes, Congo Red absorption ability and by the Sereny test performed on representative strains. Plasmid patterns were heterogeneous but more than 50% of strains were confined to a single pattern. All strains possessed a 1.6 MDa plasmid and 87% of the strains contained a 4 MDa plasmid. Middle-range plasmids (90 MDa to 30 MDa) present in 36% of the strains were not associated with antibiotic resistance. All the strains were clustered within a single type with four subtypes by pulsed-field gel electrophoresis while ribotyping patterns of all the strains were identical.
- Publication
Epidemiology & Infection, 2006, Vol 134, Issue 6, p1249
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/s0950268806006029