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- Title
The Chemopreventive Capacity of Quercetin to Induce Programmed Cell Death in Hepatocarcinogenesis.
- Authors
Vásquez-Garzón, Verónica Rocío; Macias-Pérez, José Roberto; Jiménez-García, Mónica Noemí; Villegas, Vanessa; Fattel-Fazenta, Samia; Villa-Treviño, Saúl
- Abstract
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
- Subjects
CHEMOPREVENTION; QUERCETIN; APOPTOSIS; LIVER cancer; CARCINOGENESIS; LIPID peroxidation (Biology)
- Publication
Toxicologic Pathology, 2013, Vol 41, Issue 6, p857
- ISSN
0192-6233
- Publication type
Article
- DOI
10.1177/0192623312467522