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- Title
1040-P: Evaluation of a Medtronic Enhanced Hybrid Closed-Loop (e-HCL) System during Unannounced Meals of Medium Size.
- Authors
ROY, ANIRBAN; GROSMAN, BENYAMIN; PARIKH, NEHA; WU, DI; LINTEREUR, LOUIS J.; KURTZ, NATALIE; KAUFMAN, FRANCINE R.
- Abstract
Background: Forgetting a premeal bolus can lead to hyperglycemia in patients with type 1 diabetes (T1D). A prototype e-HCL system was designed to automatically deliver basal insulin and correction boluses based on sensor glucose (SG) values. The effect of the system on hyperglycemia due to unannounced medium-sized meals was assessed. Methods: Twelve subjects with T1D aged 15-25 years (median 17 years) underwent a 1-week hotel phase of e-HCL Auto Mode use, followed by a 3-week unsupervised at-home phase of use. On the third day of the hotel phase, a ∼40gm-carbohydrate (carb) dinner was consumed without a premeal bolus. Five hours of postprandial data were analyzed and compared to data captured after 40gm-carb meals eaten during the at-home phase, but accompanied by a premeal bolus. Results: Meals without a premeal bolus resulted in postprandial SG levels statistically similar to those observed for meals accompanied by a premeal bolus (Table). Conclusion: These data suggest that e-HCL can handle unannounced medium-sized meals to a similar extent as meals of equal size accompanied by premeal boluses. This may improve overall glycemic control of patients who underestimate or frequently forget to administer premeal boluses. Disclosure: A. Roy: Employee; Self; Medtronic MiniMed, Inc. B. Grosman: Employee; Self; Medtronic. N. Parikh: None. D. Wu: None. L.J. Lintereur: Employee; Self; Medtronic MiniMed, Inc. N. Kurtz: Employee; Self; Medtronic MiniMed, Inc. F.R. Kaufman: Employee; Self; Medtronic.
- Publication
Diabetes, 2019, Vol 68, pN.PAG
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db19-1040-P