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- Title
Visceral Adiposity and Leptin Are Independently Associated with CRP in Korean Type 2 Diabetic Patients.
- Authors
Jong Suk Park; Min Ho Cho; Hai Jin Kim; Ji Sun Nam; Han Young Jung; Ji Eun Yoon; Chul Sik Kim; Young Duk Song; Chul Woo Ahn; Bong Soo Cha; Eun Jig Lee; Sung Kil Lim; Kyung Rae Kim; Hyun Chul Lee
- Abstract
The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study was to investigate the factors contributing of serum CRP and the relationship between parameters of visceral obesity measured by CT and the CRP levels and examined the association between leptin and CRP levels in type 2 diabetic patients. One hundred and fifty patients with type 2 diabetes were enrolled. These patients were recently diagnosed (≤3 years) with type 2 diabetes and were drug naive or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids (triglycerides, HDL cholesterol, and total cholesterol), plasminogen activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Fat mass assessed by dual-energy X-ray absorptionmetry and abdominal fat distribution was determined by computerized tomography scan. Serum concentration of CRP was significantly correlated with BMI γ=0.257, P<0.01) WC(γ=0.293, P<0.01) fat mass (gamma;=0.213, P<0.01), total adipose tissue (γ=0.263, P<0.01), visceral adipose tissue (γ=0.296, P<0.01), insulin (γ0.189, P=0.047), PAI-1 (γ=0.306, P<0.01), leptin (γ=0.322, P<0.01), HOMA-IR (γ=0.172, P=0.045). After adjustment for age and sex, multple regression analysis showed that serum CRP was significantly associated with leptin (β=0.326, P=0.01) and visceral adipose tissue (β=0.265, P=0.035). In conclusion, it can be concluded that serum CRP level is significantly associated with obesity, especially visceral adipose tissue and serum leptin are another important independent factors associated with CRP in Korean type 2 diabetic patients.
- Subjects
OBESITY; LEPTIN; PEOPLE with diabetes; C-reactive protein; GLYCOSYLATED hemoglobin; GLUCOSE; PLASMINOGEN activators; INSULIN resistance
- Publication
Diabetes, 2007, Vol 56, pA590
- ISSN
0012-1797
- Publication type
Article