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- Title
The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.
- Authors
Bacci, Simonetta; Ludovico, Ornella; Prudente, Sabrina; Zhang, Yuan-Yuan; Di Paola, Rosa; Mangiacotti, Davide; Rauseo, Anna; Nolan, David; Duffy, Jill; Fini, Grazia; Salvemini, Lucia; Amico, Cesare; Vigna, Carlo; Pellegrini, Fabio; Menzaghi, Claudia; Doria, Alessandro; Trischitta, Vincenzo
- Abstract
Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n = 638), type 2 diabetic patients without CAD (n = 535), and type 2 diabetic patients with CAD (n = 434) from Italy and the U.S. were studied. The proportion of 121Q carriers progressively increased in the three groups (27.4, 28.8, and 33.2%, respectively; adjusted P value = 0.027). Among diabetic patients (n = 969), 121Q carriers had an increased risk of developing type 2 diabetes before the age of 65 years (adjusted odds ratio [OR] 2.26, 95% CI 1.26-4.03; P = 0.006) and having a myocardial infarction (MI) (n = 156) by 50 years of age (3.17, 1.46-6.88, P = 0.007). The 121Q variant was also associated with an increased risk for CAD (1.47, 1.01-2.18; P = 0.049) in diabetic patients who did not smoke (n = 546). In conclusion, the ENPP1/PC-1 121Q variant is associated with a progressive deterioration of the IR-atherogenic phenotype; among diabetic individuals, it is also associated with earlier onset of type 2 diabetes and MI.
- Subjects
INSULIN resistance; TYPE 2 diabetes; ENDOCRINE diseases; DIABETES complications; HYPOGLYCEMIC agents; MYOCARDIAL infarction
- Publication
Diabetes, 2005, Vol 54, Issue 10, p3021
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.54.10.3021