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- Title
Functional and Anatomical Outcomes of Anti-Vascular Endothelial Growth Factor Treatment for Exudative Age-Related Macular Degeneration with or without Obstructive Sleep Apnea.
- Authors
Chen, Nan-Ni; Chen, Chau-Yin; Wang, Jin-Jhe; Huang, Heng-Chiao; Chen, Wei-Dar; Chen, Ching-Lung; Yang, Yao-Hsu; Lin, Meng-Hung; Kuo, Ting-Yu; Lai, Chien-Hsiung
- Abstract
(1) To investigate the functional and anatomical outcomes of anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with exudative age-related macular degeneration (AMD) with or without obstructive sleep apnea (OSA); (2) In total, 65 patients with AMD with or without OSA who received three consecutive doses of intravitreal anti-VEGF injections were enrolled. The primary outcomes—best-corrected visual acuity (BCVA) and central macular thickness (CMT)—were assessed at 1 and 3 months. Moreover, morphological changes observed through optical coherence tomography were analyzed; (3) In total, 15 of the 65 patients had OSA and were included in the OSA group; the remaining 50 patients were included in the non-OSA (control) group. At 1 and 3 months after treatment, BCVA and CMT had improved but did not differ significantly between the groups. More patients in the OSA group demonstrated subretinal fluid (SRF) resorption at 3 months after treatment than in the non-OSA group (p = 0.009). Changes in other imaging biomarkers, such as intraretinal cysts, retinal pigment epithelium detachment, hyperreflective dots, and ellipsoid zone disruptions, did not differ significantly between the groups; (4) Our results suggest that the BCVA and CMT outcomes 3 months after anti-VEGF treatment are similar between patients with and without OSA. Moreover, patients with OSA may exhibit superior SRF resorption. A large-scale prospective study is mandatory to evaluate the association between SRF resorption and visual outcomes in AMD patients with OSA.
- Subjects
MACULAR degeneration; ENDOTHELIAL growth factors; SLEEP apnea syndromes; OPTICAL coherence tomography; RHODOPSIN; BEVACIZUMAB
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 8, p7285
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24087285